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BsAg血清学转换),残留cccDNA可长期存在,但肝脏炎症缓解、肝组织病理学改善,终末期肝病发生率显著降低。  “功能性治愈”的破局方向,主要依赖于联合疗法与新型药物双轨并行。  siRNA联合免疫调节剂通过降解病毒mRNA解除免疫抑制,同时激活耗竭T细胞,将功能性治愈率从不足10%提升至30%,其中低HBsAg(<1000 IU/mL)患者可达47%。反义寡核苷酸(ASO)如Bepiro

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